It 'a dermis-aesthetic concept always connected to the world of peeling: active substances, capable of going to interfere positively on the various structures of the dermis, of extracellular matrix and the dermo-epidermal junction are semi-permeable barrier in the nature of the skin; they needed, until Today, a chemical-physical support that would allow them to overcome the barrier of the dermis. Acids peeling, that perform this action of thinning of the outer skin layers, and then allow the penetration of the various functional principles are themselves stimulant of fibroblasts, although in a very light way; however, they may become, in certain conditions, exceptional advanced carrier of biotechnologically active substances that will manifest as the true architects of a new, massive and complex activities biorivitalization, far more intense than that explicable only by exfoliating acids. This activity will gradually involve, with the integration and activation of several growth factors , all the structures of the dermis, promoting a deep and lasting repair of the skin.